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The show followed the journey of a young orphan named Santino, played by Zaijian Jaranilla. Airing for a year starting in February 2009, the series centered on Santino’s divine connection with Jesus—known to him as "Bro"—and his extraordinary ability to heal others.
The affectionate term caught on with viewers and was even featured in the 2009 ABS-CBN Christmas Station ID, Star ng Pasko.